News about Environment
and Toxicology

May 2015




Chemicals

Nordic REACH 2015 Conference

On 23 and 24 September DHI will be hosting Nordic REACH 2015. It will be the first conference in Scandinavia that will have Nordic registration and authorisation of substances for the upcoming deadline in 2018 as its focal point.

Speakers from ECHA and the Scandinavian authorities together with representatives from international industry will take stock of the present situation:

  • What is the experience we have gained so far?
  • How do we make use of this towards 2018?

The Nordic REACH Conference will be held in collaboration with the Danish Environmental Protection Agency and The Confederation of Danish Industry (DI) at DI's headquarters in Copenhagen.

Book the dates now. We look forward to sending you a separate invitation and programme.


CLP notifiers to agree on classification

One of the objectives of the Classification and Labelling (C&L) Inventory is to attain uniform classification and labelling of substances.

To further this process, ECHA together with European industry associations have initiated a pilot project among notifiers of substances. Notifiers are requested to check or compare their notifications. In case of disagreements, notifiers may start a discussion with other notifiers on the C&L Platform, where a web-based forum is available.

Request to all registrants and notifiers

A number of notifiers have been approached directly to check their notifications. However, all registrants and notifiers are encouraged to check their notifications and to use the C&L Platform to attain agreement with other parties on entries in the C&L Inventory.

For more information on classification and labelling, please consult

Peter Kortegaard
pko@dhigroup.com
Tel: +45 4516 9049


CLP and the meaning of "Placed on the market"

When the deadline for the CLP Regulation enters into force on 1 June 2015, there is still a two-year transitional period for mixtures, which have been classified and labelled according to the requirements of the previous legislation (the Dangerous Preparations Directive, DPD), but are put on the market before June 2015.

But what does "placed on the market" mean in this context? It means that on 1 June 2015 the mixture is no longer owned by the manufacturing company – they have placed it on the market.

If the formulators can prove that they have sold the mixture before 1 June 2015, they are no longer the owners even though the mixture may still be at their warehouse. The mixture is therefore covered by the two-year transition period and may be classified and labelled according to the DPD until 1 June 2017.

However, if the formulator still owns the mixture even though it is stored at a distributor’s warehouse, the formulator must comply with the CLP regulation. Consequently, they must re-label and re-pack the mixture no later than 1 June 2015.

For questions concerning the CLP Regulation, please contact

Helle M. Andersen
hma@dhigroup.com
Tel +45 4516 9023


Danish funding for innovation in new technology

Our Danish readers may be interested in giving their opinion on how investment in new technologies and solutions for the benefit of Danish industry should be allocated for the period 2016-2018.

A total of 900 mio. Danish kroner are to be allocated among nine independent Danish research and technology organisations, including DHI. Visit the website bedreinnovation.dk and see our proposals for new products and processes.

Contact

Margrethe Winther-Nielsen
mwn@dhigroup.com
Tel +45 4516 9320


Life science

REACH test requirements for reproductive toxicity changed

A new extended one-generation test replaces the former two-generation test in REACH.

Assessment of more parameters, improved level of information plus a significant reduction in the number of test animals are some of the advantages of the new test method adopted by the European Commission in February 2015. The Extended One-Generation Reproductive Toxicity Study is the official name of the test – or just EOGRTS.

Modular test method
EOGRTS is a modular test method, where breeding and assessment of a second filial (F2) generation and testing for developmental neurotoxicity (DNT) and developmental immunotoxicity (DIT) constitute distinct and independent modules.

When the REACH Regulation was adopted in 2006 one of the intentions was to reduce the number of animals involved in testing. Until now two-generation tests have been required to fulfil the information requirements for testing of substances with possible reprotoxic properties.

The complete wording of the new regulation (EU) 2015/282 can be downloaded via EUR-Lex, the official website of EU law and public EU documents.

For questions on test methods, please contact

Poul Bo Larsen
pbl@dhigroup.com
Tel: +45 4516 9478


Consumer exposure to nanomaterials

Under the agreement Better Control of Nanomaterials, the Danish EPA has commissioned a number of projects aiming to investigate and generate new knowledge on nanomaterials in consumer products. DHI has investigated consumer exposure and risk assessments of nanomaterials in products on the Danish market.

Three subreports have been published. Overall, we conclude in the reports that more research is needed to characterise the hazard to consumers exposed to nanomaterials. At present, the most appropriate approach for risk assessments is done case-by-case. At the same time, the use of nanomaterials is increasing rapidly.

The three subreports are about

A final report on risk assessment of consumer exposure will be finalised later this year.

The reports have been carried out by DHI in collaboration with consulting engineers COWI and the Danish National Research Centre for the Working Environment.

For more information, please contact

Poul Bo Larsen
pbl@dhigroup.com
Tel: +45 4516 9478


Food

Experts disagree on bisphenol A

In January 2015, the European Food Safety Authority, EFSA, announced that bisphenol A does not constitute a health risk. Both French and Danish experts disagree with EFSA. But how can you disagree with an authority and what should industry do?

Based on assessment of toxicological data, EFSA proposed that the tolerable daily intake (TDI) should be lowered from 50 µg/kg body weight per day to 4 µg/kg body weight per day. The new TDI is temporary and awaits further research.

The Danish National Food Institute, DTU Food, believes that the TDI should be as low as 0.7 µg/kg body weight per day. In 2012, the French food authority ANSES proposed that bisphenol A should be classified as possible harmful to reproduction. In their assessments both DTU Food and ANSES place great emphasis on the endocrine disrupting effects of bisphenol A.

Other bisphenols are also problematic
What should industry do? To replace bisphenol A with other bisphenols does not appear to be the solution to the problem. New research from DTU Food indicates that other bisphenols might also have endocrine disrupting effects. Rather, the answer seems to be to develop new types of packaging and screen for endocrine disrupting substances.

For more information on food contact materials and bisphenol A, please contact

Helle Buchardt Boyd 
hbb@dhigroup.com
Tel +45 4516 9097


No cyanide poisoning from ground linseed and persipan

Experts have long discussed whether it is safe to eat marzipan made of apricot kernels (known as persipan) or eat ground linseed. Both apricot kernels and linseed contain cyanogenic glycosides that may separate prussic acid (cyanide), which is very toxic.

German researchers have carried out a study on 12 people and studied the absorption of prussic acid from different amounts of ground linseed, apricot kernels, manioc and persipan.

Intensive heating destroys cyanogenic glycosides
All the above foods contain cyanogenic glycosides in relatively high concentrations and the consumption of high doses can lead to acute poisoning by blocking the energy generation in body tissues. However, due to the intensive heating during the production of persipan, the glycosides releasing the cyanide in the bitter apricot kernels are largely destroyed.

Based on the study, the German Federal Institute for Risk Assessment (BfR) concludes that you can consume as much as 15 g ground linseed per meal, and maximum two apricot kernels per day. It is safe to consume even very large quantities of marzipan and persipan, as long as the cyanide content is below 50 mg/kg. Manioc can be consumed safely if it is prepared according to traditional methods.

View the conclusion from BfR here.

For questions on food poisoning and food safety, please contact

Helle Buchardt Boyd 
hbb@dhigroup.com
Tel +45 4516 9097


New microorganisms for food and feed on QPS list

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The European Food Safety Authority, EFSA, has updated the Qualified Presumption of Safety list (QPS list). The list is used as a tool to diminish the workload of evaluating the use of microorganisms for food/feed purposes.

EFSA recommends that a further three taxonomic units are included on the QPS list:

  1. Carnobacterium divergens, with the qualification of absence of acquired antibiotic resistance determinants;
  2. Microbacterium imperiale, only for enzyme production, and
  3. Candida cylindracea, only for enzyme production.

Read more and download the updated QPS list here (please refer to paragraph 10, page 32: The 2013 updated list of QPS Status recommended biological agents in support of EFSA risk assessments 1st revision (new additions)).

For more information on microorganisms in food and feed, please contact

Ann Detmer
ad@dhigroup.com


Recipes for risk communications

A cookbook for risk assessors with principles for good risk communication is provided by EFSA and national food authorities. Besides giving good advice on choice of communications media, the cookbook contains plenty of examples including lessons learned from recent communication exercises within the field of food safety.

The guideline is available at EFSA's homepage in four different languages (English, French, German and Italian). Download the cook book When Food Is Cooking Up a Storm – Proven Recipes for Risk Communications 2015

For more information on food risk, please contact

Ann Detmer
ad@dhigroup.com


Journal of Insects as Food and Feed

Journal of Insects as Food and Feed is a new online, academic journal from Wageningen Academic Publishers. Until now, publications on insects as food and feed have been spread across journals from many scientific disciplines. Journal of Insects as Food and Feed will concentrate contributions into one readily accessible journal.

The journal aims to cover the whole chain of insect collecting or rearing to marketing edible insect products, including the development of sustainable technology and the potential to transform low value organic wastes into high protein products. At the end of the edible insect food or feed chain, consumer acceptance, food safety and regulation pose new research challenges.

View the first volume of Journal of Insects as Food and Feed (open access).

For further information, please contact

Ann Detmer
ad@dhigroup.com


Meet us

SETAC Europe 25th Annual Meeting, Barcelona
Margrethe Winther-Nielsen participates in the above conference and will present the results of a study of the ecotoxicological impact of carbon nanotubes (CNT). The conference takes place from 3-7 May in Barcelona and is hosted by the Society of Environmental Toxicology and Chemistry (SETAC).

Biocides Symposium 2015, Slovenia
On 11-13 May, Michael Fink will attend the above symposium in Ljubljana. The main focus of the event is authorisation of biocidal products.

Food Regulation Conference 2015, Copenhagen
Helle Buchardt Boyd has been invited to give a talk about food allergens on IBC Euroforum's food regulation conference in Copenhagen on 3 and 4 June.

ChemCon Asia 2015, Hong Kong
Visit our stand at ChemCon Asia 2015 on 15 – 19 June in Hong Kong. Meet Helle Westphal and Henriette Christiansen for an informal talk on chemicals regulation in Asia and worldwide.


Courses

See our remaining courses (in Danish) on our website.


Contact

DHI | Agern Allé 5 | 2970 Hørsholm | Denmark
Tel: +45 4516 9200 | Fax: +45 4516 9292 | www.tox.dhigroup.com



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